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Summary The HMB45 clone reacts with a neuraminidase-sensitive oligosaccharide side chain of a glycoconjugate present in immature melanosomes. Clone A103 recognizes a protein of 20 kDa, identified as MART-1 (melanoma antigen recognized by T cells-1) or Melan-A. Tyrosinase is a key enzyme involved in the initial stages of melanin biosynthesis. The combination of HMB45, MART-1 and tyrosinase make this triple antibody cocktail a first-order pan melanoma screener.

Summary This antibody is expected to recognise variant 1 (NP_115584) only.

Summary This antibody recognizes >90% thymocytes and approximately 40-45% mesenteric lymph node cells and immunoprecipitates a 67 kDa protein from rabbit thymocytes.

Summary Reactive with smooth muscle cells in blood vessel walls, gut wall, myometrium and arrectores pili of skin. Myoepithelial cells such as those in breast and salivary gland also contain actin.